Drug Interactions With Aluminum Hydroxide

1. Combined use with cimetidine or ranitidine is effective in relieving the pain symptoms of duodenal ulcer, but it is generally not recommended to use both within 1 hour, because cimetidine or ranitidine can be used together. absorption is reduced.

2. Aluminum hydroxide contains polyvalent aluminum ions, which can form complexes with tetracyclines and affect their absorption, so they should not be used in combination.

3. Aluminum hydroxide can interfere with warfarin, dicoumarin, quinine, quinidine, chlorpromazine, propranolol, indomethacin, isoniazid, iron salts, barbi The absorption or elimination of proper drugs will affect the efficacy of the above drugs, and simultaneous use should be avoided as much as possible.

4. When the dosage is large, it can adsorb bile salts, thereby reducing the absorption of fat-soluble vitamins and reducing the blood concentration. The two should be avoided at the same time.

5. When used in combination with digitalis glycosides, it can affect the absorption of the latter and reduce its blood concentration. The simultaneous use of the two should be avoided as much as possible.

6. When used together with enteric-coated tablets, it can accelerate the dissolution of enteric-coated coatings and stimulate the stomach and duodenum.

7. The simultaneous use of allopurinol and aluminum hydroxide in dialysis patients can cause a sharp increase in serum uric acid content, which may be due to the reduction of allopurinol absorption by aluminum hydroxide.

8. The combination of aluminum preparations and citrate may have special risks. Some studies have shown that the combination of the two may lead to a sharp rise in blood aluminum levels.